Synergistic Effect ofTaxolandVincristineAgainstMCF-7 Cell Line

Background: Women worldwide are concerned about breast cancer, resulting in high mortality and morbidity. Objectives: In this research, to investigate the function of Taxol, Vinblastine, Vincristine on MCF-7 cell line, different concentration levels (10, 20, 40, 80, 160, 320 µmol/mL) drugs were examined. Taxolwas also used combination with Vinblastine Vincristine. Methods: The examined compounds applied cells for 48 h. MTT test was employed assessing cytotoxicity, nonlinear regression method run estimate values IC50 (half maximal inhibitory concentration) values. Results: It found that taxol + vincristine, taxol, vinblastine treatments concentrations 41.45, 64.46, 67.12 µmol/mL resulted best 50% effect. lowest effective had significant effects cancer (160 µmol/mL), vincristine (80 (40 respectively (P < 0.05). Conclusions: From results current study, a synergistic reaction between based calculated CI